Hematological Effects of Certain 2,4-Diaminopyrimidines, Antagonists of Folic Acid Metabolism
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چکیده
منابع مشابه
Effects of a folic acid antagonist on nucleic acid metabolism.
Microbiological evidence (1) first implicated folic acid in nucleic acid synthesis, and several lines of investigation suggest that citrovorum factor, or another derivative of folic acid, may function in some manner as a coenzyme in the metabolism of a l-carbon moiety. The function of the formy1 group in rhizopterin (2) and citrovorum factor (3) has not been clarified. The incorporation of form...
متن کاملInhibition of nucleic acid synthesis by folic acid antagonists.
Woolley and Pringle (13) have recently reported the formation of 4-amino-5-carboxamidoimidazole during growth of Escherichia coli in the presence of 4-aminopteroylglutainic acid (aminopterin). Some of us have observed that excessive doses of folie acid speed up the leukemic process in mice and that folie acid will reverse the well known antileukemic action of aminopterin (11). This reversal of ...
متن کاملIphenylalanine Metabolism and Folic Acid
Amethopterin and related folic antagonists inhibit the reduction of folic acid to tetrahydro folic acid (2). The clinical effects of these drugs are thought to be related in turn to the role of tetrahydro folic acid in single-carbon transfer reactions during nucleic acid synthesis (3). Recently, pteridines such as folic acid have been implicated in another area of metabolism, the conversion of ...
متن کاملModification of radiation damage of bacteria by folic acid antagonists.
Pittillo, Robert F. (Southern Research Institute, Birmingham, Ala.), Mary Lucas, Robert T. Blackwell, and Carolyn Woolley. Modification of radiation damage of bacteria by folic acid antagonists. J. Bacteriol. 90:1548-1551. 1965.-The folic acid analogues, 2,4-diamino-6-methylpteridine, amethopterin, and aminopterin, have been found to sensitize certain bacteria, especially Escherichia coli, to t...
متن کاملFolic acid antagonists during pregnancy and risk of birth defects.
BACKGROUND Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and urinary tract defects in their infants. We evaluated whether the folic acid component of multivitamins is responsible for the reduction in risk by examining the associations between maternal use of folic acid antagonists and these congenital malformations. METHODS We comp...
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ژورنال
عنوان ژورنال: Blood
سال: 1954
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v9.11.1062.1062